Publication Trends of Research Articles in the Field of Osteosarcoma

Background/Objectives: The present study examines the publication trends in the field of Osteosarcoma research during 2008 to 2017. Methods/Statistical Analysis: The data have been collected from Web of Science database. The search strings were used ‘osteosarcoma’ in the Title search box, fields were used, and the time span field was selected from 2008 to 2017. Totally 6490 records were retrieved; the data downloaded and analyzed using MS office-Excel. Findings: This study identifies the year wise research output in Osteosarcoma and finds out document types, sources types, language wise publications; in this research, top fifteen sources published in Osteosarcoma research and top fifteen countries contributed. The year wise analysis shows that the data was increasing from 5.56% to 16.21%, Totally 19609 authors were contributed in Osteosarcoma research publications, among the 19609 authors, Gorlick R and Wang Y have occupied first and second place with 90 papers contributed, Zhang Y had third place with 80 papers, Picci P had fourth place with 76 contributions, remaining authors were contributed less than 75 research papers in this area; majority of the studies are collaborative contributions. Among the 97 countries contributed in this research, top fifteen countries are tabulated. China has first place with 2308 contributions, USA has seconds place with 1549 records, Japan has third place with 483 records. Among the top institutions, universities contributed more compared to other institutions. Novelty/Improvement: This research showcased the trend in Osteosarcoma research; Statistical methods were used in this study in order to analyze the evolution, and the historical development of the Osteosarcoma subject, involving some relevant aspect such as the patterns of authorship, year wise publication and growth of publications.


Introduction
Osteosarcoma is the most common bone cancer among those with non-hematological origin and affects mainly pediatric patients 1 children and adolescents, comprising 56% of all bone cancers in individuals younger than 20 years 2 . Bone cancers encompass different types of tumors, such as Ewing sarcoma and chondrosarcoma, but the most frequent among them is the osteogenic sarcoma, also known as osteosarcoma (OS), which comprises a 20-40% of total new, diagnosed bone cancers 3,4 . Indeed, osteosarcoma initiates as a monoclonal disease, which quickly develops into a polyclonal disease and is considered one of the most complex cancers in terms of molecular aberration 5 . Osteosarcoma research is growing rapidly as evidenced by the increasing research publication output. Bibliometrics is the use of quantitative analysis and statistics to describe patterns of publication within a given field or body of literature 6 . There are several bibliometric studies have reported analysis of cancer literature, but fewer only available on osteosarcoma research so far. So, the present study attempts to fill this gap by presenting research publications on osteosarcoma.
Publication Trends of Research Articles in the Field of Osteosarcoma

Materials and Methods
The relevant data have been collected from the Web of Science database covering the period from 2008 to 2017. The search string 'Osteosarcoma' in the Title search box, field were used, and the time span field select was from 2008 to 2017. Totally of 6490 records were retrieved; the data downloaded and analyzed using MS office -Excel as per objectives of the present study.

Relative Growth Rate (RGT) and Doubling Time (DT)
The Relative Growth Rate is the number of publications/ pages per unit of time. Hence, one year is taken as the unit of time. The mean relative growth rate R (1-2) over a specified period of interval can be calculated from the following equation suggested by 7 Where, R = Mean relative growth rate over the specify period of interval W1 = log W1 (Natural log of initial number of publications/pages) W2 = log W2 (Natural log of initial number of publications/pages) T2-T1 = Unit difference between the initial time and final time.
Therefore, R (a) = relative growth rate per unit per of publication per unit of time (year) R (p) = relative growth rate per unit per of pages per unit of time (year) The corresponding Doubling time for publications and pages can be calculated by using the following formula:

Objectives
To find out year wise publications in Osteosarcoma research

To identify document types contributed in Osteosarcoma research
To analysis language wise publications in Osteosarcoma research To find out authorship pattern in Osteosarcoma research

To examine top fifteen institutions contributed in Osteosarcoma
To find top fifteen Sources contributions Osteosarcoma research  Table 2 shows that, Relative Growth Rate and Doubling Time, during the study period publications, Doubling Time mean value is 10.6. In 2008, the Osteosarcoma research publication was 361; gradually the research publications were raised to 1052 in the year 2017. The relative growth rate mean is 0.11 Table 3 shows that, document types in Osteosarcoma research publications; amongst 6490 papers contributed in the twelve various document types, research article type has occupied first position with 4533 papers, followed by Meeting Abstract has 1294 records, Review has 249 records, Editorial Material has 160 records, Letter has 101 records, Proceedings Paper has 44, Correction has 36 papers and Retracted Publication and Retraction 22   Table 6 shows that authorship pattern in Osteosarcoma research publications during the study period. Among the 6490 papers, 2212 papers were six and above authors' collaborative, 1556 papers were five authors collaborations, 1002 papers are four authors collaborations, 935 papers are three authors collaborations, 476 papers is double authors collaboration, 309 papers are single author's contribution. Among the 6490 papers, majority of papers are collaborative contributions in this research during the study period, less than 5 percent of publications were contributed single author contribution. records respectively, Book Chapter has 19 records, News Item has 9 records and Poetry has 1 record. Table 4 indicates that, Language wise research publications in Osteosarcoma research during the study period. 6490 papers were published in eleven languages, amongst in English language 98.88 percent of papers have got published, followed by German language which occupies second place with 22 records, Spanish put in third place with 18 records, French in fourth place, Portuguese in fifth place, Chinese in Sixth place, Italian in seventh place, Czech in eighth place, Korean in ninth place, Turkish in tenth and Hungarian in eleventh place with single paper.

Results and Discussion
Totally 19609 authors contributed in Osteosarcoma research publications, among them, top fifteen authors are listed in this     Journal of Cancer has fourteenth and fifteenth place with 60 records contributed respectively. Moreover remaining 1110 sources were contributed below 60 records contributed in this research during the study period.